Efficacy of mecobalamin (vitamin B₁₂) in the treatment of long-term pain in women diagnosed with fibromyalgia: protocol for a randomised, placebo-controlled trial.

ABSTRACT:

Introduction

Fibromyalgia causes long-term pain. It affects at least 2% of the population, the majority being women. In addition, extended symptoms corresponding to vitamin B₁₂ deficiency occur. Findings from several studies have indicated that vitamin B₁₂ may be a possible treatment for pain in fibromyalgia. The aim of the proposed study is to evaluate whether vitamin B₁₂ decreases pain sensitivity and the experience of pain (ie, hyperalgesia and allodynia) in women with fibromyalgia.

Methods and analysis

The study is a randomised, placebo-controlled, single-blind, clinical trial with two parallel groups which are administered mecobalamin (vitamin B₁₂) or placebo over 12 weeks. 40 Swedish women aged 20-70 years with an earlier rec

SUBMITTER: Sall Hansson K 

PROVIDER: S-EPMC10069488 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature