Application of multilevel linear spline models for analysis of growth trajectories in a cohort with repeat antenatal and postnatal measures of growth: a prospective cohort study.

ABSTRACT:

Objectives

To model trajectories of antenatal and postnatal growth using linear spline multilevel models.

Design

Prospective cohort study.

Setting

Maternity hospital in Dublin, Ireland.

Participants

720-759 mother-child pairs from the ROLO study (initially a randomised control trial of a low glycaemic index diet in pregnancy to prevent recurrence of macrosomia [birth weight >4 kg]).

Primary outcomes

Trajectories of growth from 20 weeks gestation (abdominal circumference [AC], head circumference [HC] and weight) or birth (length/height) to 5 years.

Results

Over 50% of women had third-level education and 90% were of white ethnicity. Women were a mean (SD) age of 32 years (4.2) at recruitment. The best fitting model for AC, HC and weight included a m

SUBMITTER: O'Keeffe LM 

PROVIDER: S-EPMC10069489 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature