Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis.

ABSTRACT: Postoperative delirium (POD) is common. It is associated with increased morbidity and mortality. Many cases may be preventable and melatonin offers promise as a preventative agent.

Objective

This systematic review provides an up-to-date synthesis of the evidence on the effect of melatonin in preventing POD.

Design

A systematic search of randomised controlled trials of melatonin in POD was run across multiple databases (EMBASE, MEDLINE, CINAHL, PsycINFO) and a clinical trials registry (ClinicalTrials.org) (1 January 1990 to 5 April 2022). Studies examining the effects of melatonin on POD incidence in adults are included. Risk of bias was assessed using the Cochrane risk of bias 2 tool.

Outcome measures

The primary outcome is POD incidence. Secondary outcomes are POD dur

SUBMITTER: Barnes J 

PROVIDER: S-EPMC10069576 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature