Impact of prestroke physical activity and citalopram treatment on poststroke depressive symptoms: a secondary analysis of data from the TALOS randomised controlled trial in Denmark.

ABSTRACT:

Objectives

To investigate the association between prestroke physical activity and depressive symptoms up to 6 months after stroke and examine if citalopram treatment modified the association.

Design

A secondary analysis of data from the multicentre randomised controlled trial The Efficacy of Citalopram Treatment in Acute Ischemic Stroke (TALOS).

Setting and participants

TALOS was conducted at multiple stroke centres in Denmark from 2013 to 2016. It enrolled 642 non-depressed patients with first-ever acute ischaemic stroke. Patients were eligible for this study if a prestroke physical activity level was assessed by the Physical Activity Scale for the Elderly (PASE).

Interventions

All patients were randomised to citalopram or placebo for 6 months.

Outcomes

SUBMITTER: Vestergaard SB 

PROVIDER: S-EPMC10069592 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature