Optimization of guanosine-based hydrogels with boric acid derivatives for enhanced long-term stability and cell survival.

ABSTRACT: Tissue defects can lead to serious health problems and often require grafts or transplants to repair damaged soft tissues. However, these procedures can be complex and may not always be feasible due to a lack of available tissue. Hydrogels have shown potential as a replacement for tissue grafts due to their ability to support cell survival and encapsulate biomolecules such as growth factors. In particular, guanosine-based hydrogels have been explored as a potential solution, but they often exhibit limited stability which hampers their use in the biofabrication of complex grafts. To address this issue, we explored the use of borate ester chemistry and more complex boric acid derivatives to improve the stability and properties of guanosine-based hydrogels. We hypothesized that the aromatic r

SUBMITTER: Merino-Gomez M 

PROVIDER: S-EPMC10069680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature