InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma.

ABSTRACT:

Introduction

We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium.

Methods

Following a pre-established protocol, participating centers ship formalin-fixed paraffin embedded (FFPE) tissue sections to Memorial Sloan Kettering Cancer Center for the centralized handlin

SUBMITTER: Orlow I 

PROVIDER: S-EPMC10069769 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature