FGF signaling promotes spreading of fat body precursors necessary for adult adipogenesis in Drosophila.

ABSTRACT: Knowledge of adipogenetic mechanisms is essential to understand and treat conditions affecting organismal metabolism and adipose tissue health. In Drosophila, mature adipose tissue (fat body) exists in larvae and adults. In contrast to the well-known development of the larval fat body from the embryonic mesoderm, adult adipogenesis has remained mysterious. Furthermore, conclusive proof of its physiological significance is lacking. Here, we show that the adult fat body originates from a pool of undifferentiated mesodermal precursors that migrate from the thorax into the abdomen during metamorphosis. Through in vivo imaging, we found that these precursors spread from the ventral midline and cover the inner surface of the abdomen in a process strikingly reminiscent of embryonic mesoderm migra

SUBMITTER: Lei Y 

PROVIDER: S-EPMC10069774 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature