The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.

ABSTRACT: Our sense of hearing is mediated by sensory hair cells, precisely arranged and highly specialized cells subdivided into outer hair cells (OHCs) and inner hair cells (IHCs). Light microscopy tools allow for imaging of auditory hair cells along the full length of the cochlea, often yielding more data than feasible to manually analyze. Currently, there are no widely applicable tools for fast, unsupervised, unbiased, and comprehensive image analysis of auditory hair cells that work well either with imaging datasets containing an entire cochlea or smaller sampled regions. Here, we present a highly accurate machine learning-based hair cell analysis toolbox (HCAT) for the comprehensive analysis of whole cochleae (or smaller regions of interest) across light microscopy imaging modalities and speci

SUBMITTER: Buswinka CJ 

PROVIDER: S-EPMC10069775 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature