Overexpression of NgBR inhibits high-fat diet-induced atherosclerosis in ApoE-deficiency mice.

ABSTRACT:

Background

Hyperlipidemia (hypercholesterolemia and/or hypertriglyceridemia) is a risk factor for atherosclerosis. Nogo-B receptor (NgBR) plays important roles in hepatic steatosis and cholesterol transport. However, the effect of NgBR overexpression on atherosclerosis remains unknown.

Materials and methods

Apolipoprotein E deficient (ApoE-/-) mice infected with adeno-associated virus (AAV)-NgBR expression vector were fed a high-fat diet for 12 weeks, followed by determination of atherosclerosis and the involved mechanisms.

Results

We determined that high expression of NgBR by AAV injection mainly occurs in the liver and it can substantially inhibit en face and aortic root sinus lesions. NgBR overexpression also reduced levels of inflammatory factors in the aortic roo

SUBMITTER: Gong K 

PROVIDER: S-EPMC10069848 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature