Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive therapeutic target. Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis, inflammation response, and immune function. Analyzing the main members of the PDAC extracellular purinome using publicly available databases discerned which members may impact patient survival. P2RY2 presents as the purinergic gene with the strongest association with hypoxia, the highest cancer cell-specific expression, and the strongest impact on overall survival. Invasion assays using a 3D spheroid model revealed P2Y₂ to be critical in facilitating invasion

SUBMITTER: Tomas Bort E 

PROVIDER: S-EPMC10069867 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature