Copper-mediated chemodynamic therapy with ultra-low copper consumption by doping cupric ion on cross-linked (R)-(+)-lipoic acid nanoparticles.

ABSTRACT: Cu-mediated chemodynamic therapy (CDT) has attracted prominent attention owing to its advantages of pH independence and high efficiency comparing to Fe-mediated CDT, while the application of Cu-based CDT agents was impeded due to the high copper consumption caused by the metabolism loss of copper and the resultant potential toxicity. Herein, we developed a new copper-mediated CDT agent with extremely low Cu usage by anchoring copper on cross-linked lipoic acid nanoparticles (Cu@cLAs). After endocytosis into tumor cells, the Cu@cLAs were dissociated into LA and dihydrolipoic acid (DHLA) (reduced form of LA) and released Cu²⁺ and Cu⁺ (oxidized form of Cu²⁺), the two redox couples recycled each other in cells to achieve the efficient killing of cancer cells by

SUBMITTER: Cui R 

PROVIDER: S-EPMC10070036 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature