PyPheWAS Explorer: a visualization tool for exploratory analysis of phenome-disease associations.

ABSTRACT:

Objective

To enable interactive visualization of phenome-wide association studies (PheWAS) on electronic health records (EHR).

Materials and methods

Current PheWAS technologies require familiarity with command-line interfaces and lack end-to-end data visualizations. pyPheWAS Explorer allows users to examine group variables, test assumptions, design PheWAS models, and evaluate results in a streamlined graphical interface.

Results

A cohort of attention deficit hyperactivity disorder (ADHD) subjects and matched non-ADHD controls is examined. pyPheWAS Explorer is used to build a PheWAS model including sex and deprivation index as covariates, and the Explorer's result visualization for this model reveals known ADHD comorbidities.

Discussion

pyPheWAS Explorer may be

SUBMITTER: Kerley CI 

PROVIDER: S-EPMC10070037 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature