Is vaccination against COVID-19 associated with autoimmune rheumatic disease flare? A self-controlled case series analysis.

ABSTRACT:

Objectives

To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and autoimmune rheumatic disease (AIRD) flare.

Material and methods

Patients with AIRDs vaccinated against COVID-19 who consulted for disease flare between 1 December 2020 and 31 December 2021 were ascertained in Clinical Practice Research Datalink (Aurum). AIRD flare was defined as consultation for AIRD with CS prescription on the same day or the next day. Vaccination was defined using date of vaccination and product code. The observation period was partitioned into vaccine-exposed (21 days after vaccination), pre-vaccination (7 days before vaccination) and remaining vaccine-unexposed periods. Participants contributed data with multiple vaccinations and outcomes. Season

SUBMITTER: Nakafero G 

PROVIDER: S-EPMC10070057 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature