Genetic association of lipids and lipid-lowering drug target genes with non-alcoholic fatty liver disease.

ABSTRACT:

Background

Some observational studies found that dyslipidaemia is a risk factor for non-alcoholic fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk. However, it remains unclear whether dyslipidaemia is causative for NAFLD. This Mendelian randomisation (MR) study aimed to explore the causal role of lipid traits in NAFLD and evaluate the potential effect of lipid-lowering drug targets on NAFLD.

Methods

Genetic variants associated with lipid traits and variants of genes encoding lipid-lowering drug targets were extracted from the Global Lipids Genetics Consortium genome-wide association study (GWAS). Summary statistics for NAFLD were obtained from two independent GWAS datasets. Lipid-lowering drug targets that reached significance were further tested us

SUBMITTER: Li Z 

PROVIDER: S-EPMC10070091 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature