Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is a complex mental disorder featured by an increased focus on the self and emotion dysregulation whose interaction remains unclear, though. At the same time, various studies observed abnormal representation of global fMRI brain activity in specifically those regions, e.g., cortical midline structure (CMS) in MDD that are associated with the self. Are the self and its impact on emotion regulation related to global brain activity unevenly represented in CMS relative to non-CMS? Addressing this yet open question is the main goal of our study. We here investigate post-acute treatment responder MDD and healthy controls in fMRI during an emotion task involving both attention and reappraisal of negative and neutral stimuli. We first demonstrate abnormal emotion re

SUBMITTER: Keskin K 

PROVIDER: S-EPMC10070354 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature