Phenotypic plasticity promotes lymph nodes metastasis and drug resistance in lung squamous cell carcinomas.

ABSTRACT:

Background

Phenotypic plasticity (PP) is a major promoter of tumor metastasis and drug resistance. Nevertheless, the molecular features and clinical significance of phenotypic plasticity in lung squamous cell carcinomas (LSCC) remained largely unexplored.

Methods

Phenotypic plasticity-related genes (PPRG) and clinical information of LSCC were downloaded from the cancer genome atlas (TCGA). The expression profiles of PPRG were compared between patients with and without lymph node metastasis. The prognostic signature was constructed, and survival analysis was performed based on phenotypic plasticity. Immunotherapy responses, chemotherapeutic drugs and targeted drug responses were investigated. In addition, the results were verified in an external cohort.

Results

Patient

SUBMITTER: Wang F 

PROVIDER: S-EPMC10070384 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature