Repair of critical-sized bone defects in rabbit femurs using graphitic carbon nitride (g-C₃N₄) and graphene oxide (GO) nanomaterials.

ABSTRACT: Various biomaterials have been evaluated to enhance bone formation in critical-sized bone defects; however, the ideal scaffold is still missing. The objective of this study was to investigate the in vitro and in vivo regenerative capacity of graphitic carbon nitride (g-C₃N₄) and graphene oxide (GO) nanomaterials to stimulate critical-sized bone defect regeneration. The in vitro cytotoxicity and hemocompatibility of g-C₃N₄ and GO were evaluated, and their potential to induce the in vitro osteogenesis of human fetal osteoblast (hFOB) cells was assessed using qPCR. Then, bone defect in femoral condyles was created in rabbits and left empty as control or filled with either g-C₃N₄ or GO. The osteogenesis of the different implante

SUBMITTER: Sadek AA 

PROVIDER: S-EPMC10070441 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature