Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation.

ABSTRACT: The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular contexts requires further investigation. The bulk of research has been completed using in vitro studies of cancer cell lines or in vivo studies in mouse models, but much less is known about p53 action in diverse non-transformed human tissues. Here, we investigated how different cellular states modify the p53 transcriptional program in human cells through a combination of computational analyses of publicly available large-scale datasets and in vitro studies using an isogenic system consisting of induced pluripotent stem cells (iPSCs) and two deri

SUBMITTER: Tatavosian R 

PROVIDER: S-EPMC10070495 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature