Prevalence of tumour-infiltrating CD103⁺ cells identifies therapeutic-sensitive prostate cancer with poor clinical outcome.

ABSTRACT:

Background

The clinical significance and immune correlation of CD103⁺ cells in prostate cancer (PCa) remain explored.

Methods

In total, 1080 patients with PCa underwent radical prostatectomy from three cohorts were enrolled for retrospective analysis. Tumour microarrays were constructed and fresh tumour samples were analysed by flow cytometry.

Results

High CD103⁺ cell infiltration correlated with reduced biochemical recurrence (BCR)-free survival in PCa. Adjuvant hormone therapy (HT) prolonged the BCR-free survival for high-risk node-negative diseases with CD103⁺ cell abundance. CD103⁺ cell infiltration correlated with less cytotoxic expression and increased infiltration of CD8⁺ and CD4⁺ T cells, M1 mac

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC10070496 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature