The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study.

ABSTRACT:

Background

Observational studies have investigated the effect of serum lipids on kidney function, but these findings are limited by confounding, reverse causation and have reported conflicting results. Mendelian randomization (MR) studies address this confounding problem. However, they have been conducted mostly in European ancestry individuals. We, therefore, set out to investigate the effect of lipid traits on the estimated glomerular filtration rate (eGFR) based on serum creatinine in individuals of African ancestry.

Methods

We used the two-sample and multivariable Mendelian randomization (MVMR) approaches; in which instrument variables (IV's) for the predictor (lipid traits) were derived from summary-level data of a meta-analyzed African lipid GWAS (MALG, n = 24,215) fro

SUBMITTER: Kintu C 

PROVIDER: S-EPMC10070509 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature