Why the clock ticks differently in Parkinson's disease: Insights from motor imagery and resting-state functional magnetic resonance imaging.

ABSTRACT: In Parkinson's disease (PD), an impaired perception of suprasecond time intervals has been reported. From a neurobiological perspective, dopamine is thought to be an important mediator of timing. Nevertheless, it is still unclear whether timing deficits in PD occur mainly in the motor context and are associated with corresponding striatocortical loops. This study attempted to fill this gap by investigating time reproduction in the context of a motor imagery task, and its neurobiological correlates in resting-state networks of basal ganglia substructures in PD. Nineteen PD patients and 10 healthy controls therefore underwent two time reproduction tasks. In a motor imagery task, subjects were asked to walk down a corridor for 10 s and reproduce the time spent walking during motor imagery aft

SUBMITTER: Ruppert-Junck MC 

PROVIDER: S-EPMC10070529 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature