The added values of ¹⁸F-FDG PET/CT in differentiating cancer recurrence and osteoradionecrosis of mandible in patients with treated oral squamous cell carcinoma.

ABSTRACT:

Background

Osteoradionecrosis (ORN) of the jaw requires a differential diagnosis to exclude cancer recurrence. Here, we sought to develop a scoring system comprising ¹⁸F-FDG PET/CT parameters for distinguishing between the two conditions in patients with oral squamous cell carcinoma (OSCC).

Methods

The study consisted of 103 OSCC patients with suspected ORN of the jaw. All participants underwent ¹⁸F-FDG PET/CT imaging within 6 months of diagnostic histopathology. Following extraction of PET parameters, we identified clinical and imaging predictors of mandibular recurrence-free survival (MRFS) using receiver operating characteristic curve analysis and multivariate Cox regression models.

Results

The results of histopathology revealed mandibular can

SUBMITTER: Cheng NM 

PROVIDER: S-EPMC10070584 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature