Neuroprotective therapies in the NICU in term infants: present and future.

ABSTRACT: Outcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE in term and near-term infants has proven beneficial, 30-50% of infants with moderate-to-severe NE treated with TH still suffer death or significant impairments. There is therefore a critical need to find additional pharmacological and non-pharmacological interventions that improve the outcomes for these children. There are many potential candidates; however, it is unclear whether these interventions have additional benefits when used with TH. Although primary and delayed (secondary) brain injury starting in the latent phase after HI are major contributors to neurodisability, the very late evolving effects of tertiary brain inj

SUBMITTER: Molloy EJ 

PROVIDER: S-EPMC10070589 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature