3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing.

ABSTRACT: Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms of processing as well as tablet properties. In this study, an amorphous formulation, which had been printed via Fused Deposition Modeling and drop-on-powder printing, also known as binder jetting, was characterized in terms of solid-state properties and physical stability. Solid state assessment was performed by differential scanning calorimetry, powder X-ray diffraction and polarized microscopy. The supersaturation performance of the amorphous solid dispersion was assessed via non-sink dissolu

SUBMITTER: Gottschalk N 

PROVIDER: S-EPMC10070627 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature