Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent.

ABSTRACT: The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth. Our analysis identified alterations of the clock network and skeletal muscle-associated pathways, as a result of spaceflight

SUBMITTER: Malhan D 

PROVIDER: S-EPMC10070655 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature