Physiological concentration of protocatechuic acid directly protects vascular endothelial function against inflammation in diabetes through Akt/eNOS pathway.

ABSTRACT:

Background

Cardiovascular diseases (CVDs) have been the major cause of mortality in type 2 diabetes. However, new approaches are still warranted since current diabetic medications, which focus mainly on glycemic control, do not effectively lower cardiovascular mortality rate in diabetic patients. Protocatechuic acid (PCA) is a phenolic acid widely distributed in garlic, onion, cauliflower and other plant-based foods. Given the anti-oxidative effects of PCA in vitro, we hypothesized that PCA would also have direct beneficial effects on endothelial function in addition to the systemic effects on vascular health demonstrated by previous studies.

Methods and results

Since IL-1β is the major pathological contributor to endothelial dysfunction in diabetes, the anti-inflamma

SUBMITTER: Chook CYB 

PROVIDER: S-EPMC10070727 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature