Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study.

ABSTRACT:

Introduction

The metabolomic changes caused by airborne fine particulate matter (PM_2.5) exposure in patients with chronic obstructive pulmonary disease (COPD) remain unclear. The aim of this study was to determine whether it is possible to predict PM_2.5-induced acute exacerbation of COPD (AECOPD) using metabolic markers.

Methods

Thirty-eight patients with COPD diagnosed by the 2018 Global Initiative for Obstructive Lung Disease were selected and divided into high exposure and low exposure groups. Questionnaire data, clinical data, and peripheral blood data were collected from the patients. Targeted metabolomics using liquid chromatography-tandem mass spectrometry was performed on the plasma samples to investigate the metabolic differences between the tw

SUBMITTER: Yu T 

PROVIDER: S-EPMC10070744 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature