On gaps of clinical diagnosis of dementia subtypes: A study of Alzheimer's disease and Lewy body disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) and Lewy body disease (LBD) are the two most common neurodegenerative dementias and can occur in combination (AD+LBD). Due to overlapping biomarkers and symptoms, clinical differentiation of these subtypes could be difficult. However, it is unclear how the magnitude of diagnostic uncertainty varies across dementia spectra and demographic variables. We aimed to compare clinical diagnosis and post-mortem autopsy-confirmed pathological results to assess the clinical subtype diagnosis quality across these factors.

Methods

We studied data of 1,920 participants recorded by the National Alzheimer's Coordinating Center from 2005 to 2019. Selection criteria included autopsy-based neuropathological assessments for AD and LBD, and the initial visit

SUBMITTER: Wei H 

PROVIDER: S-EPMC10070837 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature