Differential metabolic host response to pathogens associated with community-acquired pneumonia.

ABSTRACT:

Background

Metabolic changes induced by the host immune response to pathogens found in patients with community-acquired pneumonia (CAP) may provide insight into its pathogenesis. In this study, we characterized differences in the host metabolic response to common CAP-associated pathogens.

Method

Targeted metabolomic profiling was performed on serum samples obtained from hospitalized CAP patients (n = 119) at admission. We quantified 347 unique metabolites across multiple biochemical classes, including amines, acylcarnitines, and signaling lipids. We evaluated if unique associations between metabolite levels and specific CAP-associated pathogens could be identified.

Results

Several acylcarnitines were found to be elevated in C. burnetii and herpes simplex virus

SUBMITTER: den Hartog I 

PROVIDER: S-EPMC10070890 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature