Predictive significance of glomerular insulin receptor substrate-1 in patients with diabetic kidney disease.

ABSTRACT:

Background

In rodents, glomerular expression of insulin receptor substrate 1 (IRS1) is decreased in diabetic kidney disease (DKD) and reduced associated functioning is involved in the development and progression of DKD. This study aimed to evaluate the significance of glomerular IRS1 expression in DKD patients, and investigated whether glomerular IRS1 expression can reflect renal pathology and predict renal outcomes.

Methods

This study included 10 patients who underwent renal biopsy and were diagnosed with DKD or minor glomerular abnormality (MGA). IRS1-positive cells were determined based on renal biopsy and immunostaining, and the associations of the number of these cells with baseline and prognostic parameters were analyzed.

Results

IRS1-positive cells were signifi

SUBMITTER: Mima A 

PROVIDER: S-EPMC10070893 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature