Causal effects of hypertension on risk of erectile dysfunction: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Erection dysfunction has been associated with hypertension in several epidemiological and observational studies. But the causal association between hypertension and erectile dysfunction requires further investigation.

Methods

A two-sample Mendelian randomization (MR) was conducted to analyze the causal effect of hypertension on risk of erection dysfunction. Large-scale publicly available genome-wide association study data were used to estimate the putative causality between hypertension and risk of erectile dysfunction. A total of 67 independent single nucleotide polymorphisms were selected as instrumental variables. Inverse-variant weighted, maximum likelihood, weighted median, penalized weighted median, and MR-PRESSO approaches were utilized in MR analyses. Hete

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10070976 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature