Lung aeration reduces blood pressure surges caused by umbilical cord milking in preterm lambs.

ABSTRACT:

Background

Umbilical cord milking (UCM) at birth causes surges in arterial blood pressure and blood flow to the brain, which may explain the high risk of intraventricular haemorrhage (IVH) in extremely preterm infants receiving UCM. This high risk of IVH has not been reported in older infants.

Objective

We hypothesized that lung aeration before UCM, reduces the surge in blood pressure and blood flow induced by UCM.

Methods

At 126 days' gestation, fetal lambs (N = 8) were exteriorised, intubated and instrumented to measure umbilical, pulmonary, cerebral blood flows, and arterial pressures. Prior to ventilation onset, the umbilical cord was briefly (2-3 s) occluded (8 times), which was followed by 8 consecutive UCMs when all physiological parameters had returned

SUBMITTER: Blank DA 

PROVIDER: S-EPMC10071016 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature