Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank.

ABSTRACT:

Purpose

To reveal relationship between air pollution exposure and osteoporosis (OP) risk.

Methods

Based on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution scores (APS) were constructed to assess the combined effects of multiple air pollutants on OP risk. Finally, we constructed a genetic risk score (GRS) based on a large genome-wide association study of femoral neck bone mineral density and assessed whether single or combined exposure to air pollutants modifies the effect of genetic risk on OP and fracture risk.

Results

PM_2.5, NO₂, NO_x, and APS were significantly associated with an increased risk of OP/fracture. OP and fracture risk raised with increasin

SUBMITTER: Yu XH 

PROVIDER: S-EPMC10071034 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature