Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn's disease patients with isolated anastomotic lesions.

ABSTRACT:

Background

Patients with isolated anastomotic lesions (iAL) are common in postoperative Crohn's disease (CD) and have heterogeneous prognosis.

Objectives

To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in CD patients with iAL.

Design

A bicenter retrospective cohort study.

Methods

CD patients who received ileocolonic resection from 2013 and 2020 and had a modified Rutgeerts score of i2a were recruited. NLR was determined within 1 week around the initial endoscopy after ileocolectomy. The primary outcome was clinical recurrence. Kaplan-Meier method and Cox hazard regression analysis were utilized to assess the association between candidate variables and outcomes of interest.

Results

In total, 411 postoperative CD patients were p

SUBMITTER: Chen R 

PROVIDER: S-EPMC10071151 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature