Project description:The obesity epidemic continues to challenge global health, driven by multifaceted environmental and biological factors. Here, we investigate the impact of food insecurity, characterized by unpredictable food access, on body weight, food intake, and body composition in mice. Male and female C57BL/6J mice were subjected to a combination of intermittent fasting and 5% calorie restriction to resemble food insecurity situations. Our results reveal that this novel food insecurity model promotes fat accumulation and decreases lean mass in both sexes on a standard chow diet. While food insecurity did not exacerbate fat gain in male mice fed a high-fat diet, it further reduced lean mass. RNA sequencing of epididymal white adipose tissue from food-insecure male mice identified upregulated lipid metabolism genes and downregulated immune response genes, suggesting adipocyte expansion and potential immunity dysfunction. These results challenge the traditional view that obesity is solely driven by positive energy balance. Instead, our findings highlight the role of food insecurity in promoting metabolic adaptations favouring fat storage. Our data provide biological mechanisms that may explain the dramatic rise in obesity, underscoring the importance of socio-economic factors, beyond diet composition and energy balance, in understanding the complex etiology of obesity.

2025-06-04 | GSE274149 | GEO

Food Insecurity in Families With Critically Ill Children: A Single-Center Observational Study in Pittsburgh.

Project description: Not available

| S-EPMC8023718 | biostudies-literature

Household food insecurity and dietary patterns in rural and urban American Indian families with young children.

Project description: Not available

| S-EPMC5493116 | biostudies-literature

Temporal examination of adult food insecurity amongst Canadian families managing food allergy.

Project description: Not available

| S-EPMC10221737 | biostudies-literature

Pre-pandemic to early-pandemic changes in risk of household food insecurity among Maryland families with children.

Project description: Not available