Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.

ABSTRACT:

Background

Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear.

Methods

Plasma samples were collected from pregnant women and non-pregnant individuals (male and female) with (n = 72 pregnant, 52 non-pregnant) and without (n = 29 pregnant, 41 non-pregnant) COVID-19. COVID-19 patients were grouped as asymptomatic, mild, moderate, severe, or critically ill according to NIH classifications. Proteomic profiling of 7,288 analytes corresponding to 6,596 unique protein targets was performed using the SOMAmer platform.

Results

Herein, we profile the plasma proteome of pregnant and non-pregnant COVID-19 pa

SUBMITTER: Gomez-Lopez N 

PROVIDER: S-EPMC10071476 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature