FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.

ABSTRACT: SARS-CoV-2 can cause acute respiratory distress and death in some patients¹. Although severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers inflammation is not clear². Monocytes and macrophages are sentinel cells that sense invasive infection to form inflammasomes that activate caspase-1 and gasdermin D, leading to inflammatory death (pyroptosis) and the release of potent inflammatory mediators³. Here we show that about 6% of blood monocytes of patients with COVID-19 are infected with SARS-CoV-2. Monocyte infection depends on the uptake of antibody-opsonized virus by Fcγ receptors. The plasma of vaccine recipients does not promote antibody-dependent monocyte infection. SARS-CoV-2 begins to replicate in monocytes, but infection is ab

SUBMITTER: Junqueira C 

PROVIDER: S-EPMC10071495 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature