Combined treatment with glucosamine and chondroitin sulfate improves rheumatoid arthritis in rats by regulating the gut microbiota.

ABSTRACT:

Background

To investigate the ameliorative effects of glucosamine (GS), chondroitin sulphate (CS) and glucosamine plus chondroitin sulphate (GC) on rheumatoid arthritis (RA) in rats, and to explore the mechanism of GS, CS and GC in improving RA based on the gut microbiota.

Methods

RA rat models were effectively developed 14 days after CFA injection, and then garaged with GS, CS and GC. Body weight and paw volume of rats were monitored at multiple time points at the beginning of CFA injection. Until D₃₆, serum and ankle tissue specimens were used to measure levels of circulating inflammatory factors (TNF-α, IL-1β, MMP-3, NO and PGE₂) and local inflammatory indicators (TLR-4 and NF-κB). On D₁₈, D₂₅, and D₃₆, intergroup gut

SUBMITTER: Wang X 

PROVIDER: S-EPMC10071728 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature