The putative methyltransferase LaeA regulates mycelium growth and cellulase production in Myceliophthora thermophila.

ABSTRACT:

Background

Filamentous fungi with the ability to use complex carbon sources has been developed as platforms for biochemicals production. Myceliophthora thermophila has been developed as the cell factory to produce lignocellulolytic enzymes and plant biomass-based biofuels and biochemicals in biorefinery. However, low fungal growth rate and cellulose utilization efficiency are significant barriers to the satisfactory yield and productivity of target products, which needs our further exploration and improvement.

Results

In this study, we comprehensively explored the roles of the putative methyltransferase LaeA in regulating mycelium growth, sugar consumption, and cellulases expression. Deletion of laeA in thermophile fungus Myceliophthora thermophila enhanced mycelium growth a

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC10071736 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature