Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation.

ABSTRACT:

Background

The protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple morphologically distinct life forms. A key process for transmission of the disease is the development of male and female gametocytes in the human blood, yet the mechanisms determining sexual dimorphism in these haploid, genetically identical sexual precursor cells remain largely unknown. To understand the epigenetic program underlying the differentiation of male and female gametocytes, we separated the two sexual forms by flow cytometry and performed RNAseq as well as comprehensive ChIPseq profiling of several histone variants and modifications.

Results

We show that in female gametocytes the chromatin landscape is globally remodelled w

SUBMITTER: Jeninga MD 

PROVIDER: S-EPMC10071754 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature