Association between gut microbial diversity and technique failure in peritoneal dialysis patients.

ABSTRACT:

Background

Gut dysbiosis in peritoneal dialysis (PD) patients causes chronic inflammation and metabolic disorders which result in a series of complications, probably playing an important role in PD technique failure. The reduction in gut microbial diversity was a common feature of gut dysbiosis. The objective was to explore the relationship between gut microbial diversity and technique failure in PD patients.

Methods

The gut microbiota was analyzed by 16s ribosomal RNA gene amplicon sequencing. Cox proportional hazards models were used to identify association between gut microbial diversity and technique failure in PD patients.

Results

In this study, a total of 101 PD patients were enrolled. During a median follow-up of 38 months, we found that lower diversity was ind

SUBMITTER: Guo S 

PROVIDER: S-EPMC10071986 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature