The F₁F_o-ATP synthase α subunit of Candida albicans induces inflammatory responses by controlling amino acid catabolism.

ABSTRACT: Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously demonstrated that a Candida albicans F₁F_o-ATP synthase α subunit deletion mutant was nonlethal to mice. Here, the potential effects of the F₁F_o-ATP synthase α subunit on host inflammatory responses and the mechanism were studied. Compared with wild-type strain, the F₁F_o-ATP synthase α subunit deletion mutant failed to induce inflammatory responses in Galleria mellonella and murine systemic candidiasis models and significantly decreased the mRNA levels of the proinflammator

SUBMITTER: Li S 

PROVIDER: S-EPMC10072111 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature