Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes.

ABSTRACT: We report the synthesis and characterization of a group of benzoylhydrazones (Lⁿ) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH₃, OCH₃, OH and NH₂, for L^1-7, respectively; in L⁸ isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compounds were characterized by elemental analysis and mass spectrometry as well as by FTIR, UV-visible absorption, NMR or electron paramagnetic resonance spectroscopies. Complexes isolated in the solid state (1-8) are either formulated as [Cu(HL)acetate] (with L¹ and L⁴) or as [Cu(Lⁿ

SUBMITTER: Ribeiro N 

PROVIDER: S-EPMC10072326 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature