Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids.

ABSTRACT: Technically, symptom of offspring asthma is also closely reliant on its maternal high-fiber diet as well as the intestinal microbiome. Fruits and vegetables are abundant in inulin, and this naturally soluble dietary fiber is endowed with a potential value on offspring asthma control through the maternal intake, but the mechanism now remains less studied. In this study, rats were given with inulin-included drinking water, whereas in normal group rats were allowed with normal water. Afterwards, we analyzed both the formations of the offspring intestinal microbiome ahead of asthma model establishment and of the maternal intestinal microbiome through high throughput sequence and the short-chain fatty acids (SCFAs) by metabolomic analysis. Subsequently, lung inflammation indexes were detected b

SUBMITTER: Yuan G 

PROVIDER: S-EPMC10072493 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature