Molecular mimicry of host short linear motif-mediated interactions utilised by viruses for entry.

ABSTRACT: Viruses are obligate intracellular parasites that depend on host cellular machinery for performing even basic biological functions. One of the many ways they achieve this is through molecular mimicry, wherein the virus mimics a host sequence or structure, thereby being able to hijack the host's physiological interactions for its pathogenesis. Such adaptations are specific recognitions that often confer tissue and species-specific tropisms to the virus, and enable the virus to utilise previously existing host signalling networks, which ultimately aid in further steps of viral infection, such as entry, immune evasion and spread. A common form of sequence mimicry utilises short linear motifs (SLiMs). SLiMs are short-peptide sequences that mediate transient interactions and are major elements

SUBMITTER: Goswami S 

PROVIDER: S-EPMC10072811 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature