Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers.

ABSTRACT:

Background and aims

Two of the most lethal gastrointestinal (GI) cancers, gastric cancer (GC) and colon cancer (CC), are ranked in the top five cancers that cause deaths worldwide. Most GI cancer deaths can be reduced by earlier detection and more appropriate medical treatment. Unlike the current "gold standard" techniques, non-invasive and highly sensitive screening tests are required for GI cancer diagnosis. Here, we explored the potential of metabolomics for GI cancer detection and the classification of tissue-of-origin, and even the prognosis management.

Methods

Plasma samples from 37 gastric cancer (GC), 17 colon cancer (CC), and 27 non-cancer (NC) patients were prepared for metabolomics and lipidomics analysis by three MS-based platforms. Univariate, multivariate, and

SUBMITTER: Song G 

PROVIDER: S-EPMC10073066 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature