Serum ¹H nuclear magnetic resonance-based metabolomics of sole lesion development in Holstein cows.

ABSTRACT: Sole hemorrhage and sole ulcers, referred to as sole lesions, are important causes of lameness in dairy cattle. We aimed to compare the serum metabolome of dairy cows that developed sole lesions in early lactation with that of cows that remained unaffected. We prospectively enrolled a cohort of 1,169 Holstein dairy cows from a single dairy herd and assessed animals at 4 time points: before calving, immediately after calving, early lactation, and late lactation. Sole lesions were recorded by veterinary surgeons at each time point, and serum samples were collected at the first 3 time points. Cases were defined by the presence of sole lesions in early lactation and further subdivided by whether sole lesions had been previously recorded; unaffected controls were randomly selected to match case

SUBMITTER: Barden M 

PROVIDER: S-EPMC10073068 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature