Machine learning model to predict obesity using gut metabolite and brain microstructure data.
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ABSTRACT:
SUBMITTER: Osadchiy V
PROVIDER: S-EPMC10073225 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
Machine learning model to predict obesity using gut metabolite and brain microstructure data.
Osadchiy Vadim V Bal Roshan R Mayer Emeran A EA Kunapuli Rama R Dong Tien T Vora Priten P Petrasek Danny D Liu Cathy C Stains Jean J Gupta Arpana A
Scientific reports 20230404 1
A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions may contribute to obesity pathogenesis. In this study, we use a machine learning approach to leverage the enormous amount of microstructural neuroimaging and fecal metabolomic data to better understand key drivers of the obese compared to overweight phenotype. Our findings reveal that although gut-derived factors play a role in this distinction, it is primarily brain-directed changes that differ ...[more]
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