Metalloradical approach for concurrent control in intermolecular radical allylic C-H amination.

ABSTRACT: Although they offer great potentials, the high reactivity and diverse pathways of radical chemistry pose difficult problems for applications in organic synthesis. In addition to the differentiation of multiple competing pathways, the control of various selectivities in radical reactions presents both formidable challenges and great opportunities. To regulate chemoselectivity and regioselectivity, as well as diastereoselectivity and enantioselectivity, calls for the formulation of conceptually new approaches and fundamentally different governing principles. Here we show that Co(II)-based metalloradical catalysis enables the radical chemoselective intermolecular amination of allylic C-H bonds through the employment of modularly designed D₂-symmetric chiral amidoporphyrins with a t

SUBMITTER: Xu P 

PROVIDER: S-EPMC10073309 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature