Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons.

ABSTRACT: Autapses selectively form in specific cell types in many brain regions. Previous studies have also found putative autapses in principal spiny projection neurons (SPNs) in the striatum. However, it remains unclear whether these neurons indeed form physiologically functional autapses. We applied whole-cell recording in striatal slices and identified autaptic cells by the occurrence of prolonged asynchronous release (AR) of neurotransmitters after bursts of high-frequency action potentials (APs). Surprisingly, we found no autaptic AR in SPNs, even in the presence of Sr²⁺. However, robust autaptic AR was recorded in parvalbumin (PV)-expressing neurons. The autaptic responses were mediated by GABA_A receptors and their strength was dependent on AP frequency and number. Furt

SUBMITTER: Wang X 

PROVIDER: S-EPMC10073377 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature